A UFC Heavyweight Championship bout between Francis Ngannou and current champion Stipe Miocic served as the event headliner.
The event also featured a UFC Light Heavyweight Championship bout between current champion Daniel Cormier and Volkan Oezdemir. 
A welterweight bout between The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman and Emil Weber Meek was originally scheduled for UFC 219. But because of an alleged visa issue for Meek which affected his traveling program, the pairing was delayed and then rescheduled for this particular occasion.  But, it was changed to UFC Fight Night: Stephens vs. Choi a day after, which took place six days prior to this event. 
A welterweight bout between Abdul Razak Alhassan and Sabah Homasi was originally scheduled for UFC 219, but later shifted for this occasion. When Alhassan acquired via a controversial TKO the pairing met earlier at UFC 218. 
Charles Rosa was expected to confront promotional novice Dan Ige in the occasion. On December 22, Rosa pulled injury.  Ige remained on the card and confronted fellow newcomer Julio Arce. 
Arnold Allen was anticipated to face The Ultimate Fighter: Latin America 2 lightweight winner Enrique Barzola in the occasion. However, Allen was pulled from the fight on January 11 because of alleged visa issues which limited his ability to travel.  novice Matt Bessette that is promotional replaced him. 
Jamie Moyle was anticipated to confront Maryna Moroz in the event. However, Moyle pulled from the fight during the week leading up to the event citing an undisclosed injury.  In turn, advertising officials indicated that Moroz will be rescheduled for a future occasion.
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